Bring a large pot of salted water to a boil. Cook the pasta according to package instructions until al dente. Reserve ½ cup of pasta water, then drain and set aside.
Toss the chicken pieces with Cajun seasoning, smoked paprika, garlic powder, and onion powder in a bowl.
Heat olive oil in a large skillet over medium-high heat. Add the chicken and cook for 5-7 minutes until golden brown and cooked through. Remove the chicken and set aside.
In the same skillet, melt the butter over medium heat. Add the minced garlic and sauté for 1 minute until fragrant.
Stir in the heavy cream, Parmesan cheese, chicken broth, Cajun seasoning, and crushed red pepper flakes. Cook for 3-4 minutes, stirring constantly, until the sauce thickens slightly.
Add the cooked pasta and chicken to the skillet. Toss to coat everything in the creamy sauce.
If the sauce is too thick, add reserved pasta water, one tablespoon at a time, until you reach your desired consistency.
Season and Serve
Taste and adjust the seasoning with salt and black pepper as needed.
Garnish with fresh parsley and extra Parmesan cheese before serving.
Serve immediately while hot. Pair with garlic bread or a fresh green salad for a complete meal.
Notes
Use quality chicken, adjust spice levels to taste, reserve pasta water for adjusting sauce thickness, and try different fresh herbs for garnishing.